- Trials with a EudraCT protocol (51)
- Paediatric studies in scope of Art45 of the Paediatric Regulation (5)
51 result(s) found for: Congenital Heart Defect.
Displaying page 1 of 3.
EudraCT Number: 2010-019713-21 | Sponsor Protocol Number: CS/2007/2678 | Start Date*: 2010-06-17 | ||||||||||||||||||||||||||
Sponsor Name:University Hospitals Bristol NHS Foundation Trust | ||||||||||||||||||||||||||||
Full Title: A RANDOMISED CONTROLLED TRIAL TO COMPARE NORMOXIC VERSUS STANDARD CARDIOPULMONARY BYPASS IN CYANOTIC CHILDREN UNDERGOING CARDIAC SURGERY | ||||||||||||||||||||||||||||
Medical condition: The study investigates reoxygenation injury in cyanotic paediatric patients undergoing on-pump cardiac surgery. The types of heart condition being investigated result in chronic low blood oxygen sa... | ||||||||||||||||||||||||||||
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Population Age: Infants and toddlers, Children, Under 18 | Gender: Male, Female | |||||||||||||||||||||||||||
Trial protocol: GB (Completed) | ||||||||||||||||||||||||||||
Trial results: View results |
EudraCT Number: 2015-005507-89 | Sponsor Protocol Number: 191190 | Start Date*: 2016-08-15 | |||||||||||
Sponsor Name:Department of Cardio-Thoracic and Vascular Surgery, Aarhus University Hospital | |||||||||||||
Full Title: The pulmonary effect of bronchodilation on adult VSD patients with persistent or surgically corrected VSD | |||||||||||||
Medical condition: | |||||||||||||
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Population Age: Adults | Gender: Male, Female | ||||||||||||
Trial protocol: DK (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2013-004322-28 | Sponsor Protocol Number: P120910 | Start Date*: Information not available in EudraCT | |||||||||||
Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | |||||||||||||
Full Title: | |||||||||||||
Medical condition: | |||||||||||||
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Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18, Adults | Gender: Male, Female | ||||||||||||
Trial protocol: FR (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2010-020209-33 | Sponsor Protocol Number: 07052010 | Start Date*: 2010-10-12 | ||||||||||||||||
Sponsor Name:University Hospitals Leuven | ||||||||||||||||||
Full Title: BOsentan for Mild Pulmonary vascular disease in Asd patients (the BOMPA trial): a double-blind, randomized controlled, pilot trial | ||||||||||||||||||
Medical condition: Repaired (after the age of 40) atrial septal defect patients older than 40 years with evidence of mild pulmonary vascular disese as assessed by bicycle stress echocardiography. | ||||||||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | |||||||||||||||||
Trial protocol: BE (Completed) | ||||||||||||||||||
Trial results: View results |
EudraCT Number: 2011-003325-10 | Sponsor Protocol Number: 1.01 | Start Date*: 2012-08-10 | |||||||||||||||||||||
Sponsor Name:VU University Medical Center | |||||||||||||||||||||||
Full Title: A randomized controlled trail on the effects of periconceptional and prenatal folic acid supplementation on congenital anomalies and preterm birth | |||||||||||||||||||||||
Medical condition: congenital anomalies | |||||||||||||||||||||||
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Population Age: Adults | Gender: Female | ||||||||||||||||||||||
Trial protocol: NL (Ongoing) | |||||||||||||||||||||||
Trial results: (No results available) |
EudraCT Number: 2012-003335-33 | Sponsor Protocol Number: AC-055-305 | Start Date*: 2013-02-27 | |||||||||||
Sponsor Name:Actelion Pharmaceuticals Ltd. | |||||||||||||
Full Title: A multi-center, double-blind, randomized, placebo-controlled, parallel-group, Phase 3 study to evaluate the effects of macitentan on exercise capacity in subjects with Eisenmenger Syndrome. | |||||||||||||
Medical condition: Eisenmenger Syndrome | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: GB (Completed) IT (Completed) BG (Completed) BE (Completed) DE (Completed) PT (Completed) NL (Completed) AT (Completed) ES (Completed) HU (Completed) CZ (Completed) GR (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2016-003495-53 | Sponsor Protocol Number: NL59009.018.16 | Start Date*: 2016-11-29 |
Sponsor Name:Academic Medical Center - Cardiology | ||
Full Title: Prostacyclin receptor agonist Selexipag in patients with pulmonary arterial hypertension and congenital heart disease | ||
Medical condition: Pulmonary arterial hypertension related to congenital heart disease. | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: NL (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2012-004411-31 | Sponsor Protocol Number: AC-055-308 | Start Date*: 2013-02-01 | |||||||||||
Sponsor Name:ACTELION PHARMACEUTICALS LTD. | |||||||||||||
Full Title: Long term, single-arm, open-label extension study of protocol AC-055-305 to assess the safety, tolerability and efficacy of macitentan in subjects with Eisenmenger Syndrome. | |||||||||||||
Medical condition: Eisenmenger Syndrome | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: IT (Completed) BG (Completed) GB (Completed) DE (Completed) AT (Completed) PT (Completed) ES (Completed) HU (Completed) CZ (Completed) RO (Completed) PL (Completed) GR (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2011-005440-98 | Sponsor Protocol Number: | Start Date*: 2012-04-12 | |||||||||||
Sponsor Name:AKH Linz | |||||||||||||
Full Title: Double blinded randomised trial for the evaluation of the effectiveness of prophylactic use of sildenafil for the prevention of pulmonary hypertensive crisis after congenital heart surgery | |||||||||||||
Medical condition: Ventriculs septal defect, atrioventricular canal with pulmonary hypertension | |||||||||||||
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Population Age: Newborns, Infants and toddlers, Under 18 | Gender: Male, Female | ||||||||||||
Trial protocol: AT (Completed) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2007-002774-64 | Sponsor Protocol Number: HP 3.1 | Start Date*: 2007-12-04 |
Sponsor Name:Deutsches Herzzentrum Berlin, Kompetenznetz Angeborene Herzfehler | ||
Full Title: Therapy of PAH – Treatment with Sildenafil in Eisenmenger Patients | ||
Medical condition: Patients with pre-existing congenital heart disease may develop Eisenmenger physiology (EP), characterized by development of pulmonary arterial hypertension and intracardiac right to left shunt. Th... | ||
Disease: | ||
Population Age: Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: DE (Prematurely Ended) | ||
Trial results: (No results available) |
EudraCT Number: 2006-004705-26 | Sponsor Protocol Number: CRO529 | Start Date*: 2007-05-10 | |||||||||||
Sponsor Name:Imperial College London | |||||||||||||
Full Title: Safety and Tolerability of Sildenafil in Patients with Eisenmenger Physiology | |||||||||||||
Medical condition: Eisenmenger Syndrome (pulmonary hypertension due to congenital heart disease) | |||||||||||||
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Population Age: Adults | Gender: Male, Female | ||||||||||||
Trial protocol: GB (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2011-001187-21 | Sponsor Protocol Number: SCRM-001 | Start Date*: 2011-11-28 | |||||||||||
Sponsor Name:University of Zurich | |||||||||||||
Full Title: A Phase I/II, Open Monocentric Study To Evaluate The Safety And Efficacy Of An Autologous Tissue-Engineered Vascular Graft In Peadiatric Patients Requiring Reconstruction Of Right Ventricle Outflow... | |||||||||||||
Medical condition: functional single ventricle physiology functional single left ventricle functional single right ventricle functional single biventricle | |||||||||||||
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Population Age: Children, Under 18 | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Temporarily Halted) | |||||||||||||
Trial results: View results |
EudraCT Number: 2019-001759-38 | Sponsor Protocol Number: K675 | Start Date*: 2019-12-04 |
Sponsor Name:Ruprecht-Karls University Heidelberg Medical Faculty, University Hospital represented in law by its commercial director | ||
Full Title: Pharmacokinetics of a microdosed cocktail containing rivaroxaban, apixaban and edoxaban in children with congenital heart defects | ||
Medical condition: 20 children with non-cyanotic congenital heart defects especially atrial septal defects (ASD) and ventricular septal defects (VSD) in admitted to the paediatric cardiology wards will be included. T... | ||
Disease: | ||
Population Age: Children, Under 18 | Gender: Male, Female | |
Trial protocol: DE (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2022-000608-36 | Sponsor Protocol Number: UKER-MFHO-01 | Start Date*: 2022-11-07 | |||||||||||
Sponsor Name:Universitätsklinikum Erlangen | |||||||||||||
Full Title: Prospective, randomized, controlled, open, multicenter clinical trial on the efficacy and safety of materno-fetal hyperoxygenation (MFHO) during the third trimester of pregnancy to treat underdevel... | |||||||||||||
Medical condition: underdeveloped left ventricular structures in human fetus | |||||||||||||
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Population Age: In utero, Under 18, Adults | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Trial now transitioned) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2016-002427-28 | Sponsor Protocol Number: CIT-003-01 | Start Date*: 2018-10-24 |
Sponsor Name:Asklepion Pharmaceuticals, LLC | ||
Full Title: A Phase III Double-Blind, Randomized, Placebo Controlled, Multi-Center Clinical Study to Evaluate the Efficacy and Safety of Intravenous L-citrulline for the Prevention of Clinical Sequelae of Acut... | ||
Medical condition: Post-operative pulmonary dysfunction induced by cardiopulmonary bypass in pediatric subjects undergoing surgery for congenital heart defects. | ||
Disease: | ||
Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18, Adults | Gender: Male, Female | |
Trial protocol: DE (Completed) AT (Completed) | ||
Trial results: (No results available) |
EudraCT Number: 2019-002533-11 | Sponsor Protocol Number: AC-055-315 | Start Date*: 2020-06-17 | |||||||||||
Sponsor Name:ACTELION Pharmacteuticals Ltd. | |||||||||||||
Full Title: A Phase 3, Prospective, Multicenter, Double-blind, Double-dummy, Randomized, Active-controlled, Parallel-group, Group-sequential, Adaptive, Event-driven Study to Compare Efficacy, Safety, and Toler... | |||||||||||||
Medical condition: Pulmonary arterial hypertension | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Ongoing) CZ (Ongoing) HU (Ongoing) SE (Ongoing) GB (GB - no longer in EU/EEA) DK (Ongoing) NL (Ongoing) PL (Ongoing) PT (Ongoing) BE (Ongoing) NO (Completed) SK (Ongoing) AT (Ongoing) IT (Ongoing) BG (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2016-003181-12 | Sponsor Protocol Number: HOTPOT1 | Start Date*: 2016-10-07 |
Sponsor Name:Royal College of Surgeons in Ireland | ||
Full Title: Can sonographic assessment of pulmonary vascular reactivity following maternal hyperoxygenation therapy predict neonatal outcome in fetuses at risk of pulmonary hypertension? | ||
Medical condition: Persistent pulmonary hypertension of the newborn (PPHN) is a relatively common condition occurring in 7/1000 births and can result in significant cardiovascular instability in the newborn. It occur... | ||
Disease: | ||
Population Age: Adults | Gender: Female | |
Trial protocol: IE (Completed) | ||
Trial results: View results |
EudraCT Number: 2017-000137-31 | Sponsor Protocol Number: 2017-2019 | Start Date*: 2017-12-19 | ||||||||||||||||
Sponsor Name:VU University Medical Center | ||||||||||||||||||
Full Title: Pulmonary Hypertension REversal in Clusters of Patients With Identical Pathobiological Substrates. 6-Mercaptopurine Proof-of-Concept Trial | ||||||||||||||||||
Medical condition: Pulmonary arterial hypertension | ||||||||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | |||||||||||||||||
Trial protocol: NL (Prematurely Ended) | ||||||||||||||||||
Trial results: View results |
EudraCT Number: 2018-002448-10 | Sponsor Protocol Number: BIA-51058-201 | Start Date*: 2018-10-31 |
Sponsor Name:Bial - Portela & Ca, S.A. | ||
Full Title: An open-label, multicentre study to evaluate pharmacokinetics, safety and efficacy of zamicastat as adjunctive therapy in pulmonary arterial hypertension (PAH) | ||
Medical condition: Pulmonary arterial hypertension | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: AT (Completed) DE (Completed) PT (Completed) ES (Ongoing) GB (Temporarily Halted) IT (Completed) | ||
Trial results: (No results available) |
EudraCT Number: 2008-003482-68 | Sponsor Protocol Number: BAY 63-2521/12934 | Start Date*: 2008-11-26 | |||||||||||
Sponsor Name:Bayer HealthCare AG | |||||||||||||
Full Title: Randomized, double-blind, placebo-controlled, multi-centre, multi-national study to evaluate the efficacy and safety of oral BAY 63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg tid) in patients with symptom... | |||||||||||||
Medical condition: Pulmonary Arterial Hypertension (PAH) | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Completed) IE (Prematurely Ended) AT (Completed) ES (Completed) NL (Completed) FR (Completed) SE (Completed) GB (Completed) CZ (Completed) DK (Completed) BE (Completed) IT (Completed) PT (Completed) GR (Completed) | |||||||||||||
Trial results: View results |
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